lymphoid hyperplasia base of tongue

https://doi.org/10.1200/JCO.2005.07.155. As both peripheral T cell lymphoma and MCL are extremely rare in the tongue base, we would like to describe these two cases in detail as follows. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. Pictorial review: principles of double-contrast pharyngography. One patient in the literature died 18months after diagnosis despite being in an early stage. Among our cases, there were 1 GC and 3 NGC cases. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. Paracortical hyperplasia may be accompanied by vascular proliferation. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. Imaging and pathological findings of DLBCL (case 5). Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. 1, pp. Springer Nature. In special cases, several biopsies are needed. a. CT showed a well-bordered cystic mass. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to the paucity of cases. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). DLBCL with high risk factors and MCL may have unfavourable outcomes. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. 1. 2012;28:43541. 2). She started rituximab-CHOP(R-CHOP) regimen. and transmitted securely. 2018 Aug;275(8):1945-1953. doi: 10.1007/s00405-018-5041-1. Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity. 4th ed. Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. The condition mainly affects adult patients, ranging. 1),and two cases expressed c-Myc(>40%). Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. Chi HS, Lee KW, Chiang FY, Tai CF, Wang LF, Yang SF, Lin SF, Kuo WR. Int J Hematol. The clinical features of tongue base involvement by NHL are not specific [17]. 1998;18:38792. https://doi.org/10.1159/000278291. Healy JA, Dave SS. CAS Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). 37, no. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). official website and that any information you provide is encrypted https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. Severe benign LH is unusual in the head and neck region, but the diagnosis should be entertained on the part of the clinician both clinically and histologically when lymphoma is suspectedparticularly in the oral cavity. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). After washing and amplification, target RNA was stained with DAB. Her IPI score was 3 (high risk group). The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. .. The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. Doctors typically provide answers within 24 hours. https://doi.org/10.1002/cncr.27988. Am J Otolaryngol. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. St. Louis, MO: Elsevier; 2017. Videofluorography swallow study of patients with systemic sclerosis. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. Two patients, including our patient, died during follow-up. https://doi.org/10.11406/rinketsu.58.2033. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. J Clin Oncol. 2014;118:33847. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. government site. 4, pp. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). Imaging and pathological findings of MCL (case 2). Call your doctor or 911 if you think you may have a medical emergency. Baran et al. Owosho AA, Bilodeau EA, Surti U, Craig FE. The remaining five patients were alive through the end of follow up. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. Samples were assayed using a BOND HPV probe set specific to HPV subtypes 16, 18, 31, 33 and 51 (Bond Ready-to-Use ISH HPV Probe, CAT # PB0829) on the Leica BOND-MAX system. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. https://doi.org/10.1016/S0344-0338(11)80514-5. https://doi.org/10.1016/j.ijom.2010.03.029. Acta Oncol. Spectrum of a benign entity. Never disregard or delay professional medical advice in person because of anything on HealthTap. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17, 27, 40]. Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. Bethesda, MD 20894, Web Policies EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. government site. An official website of the United States government. Int J Oral Maxillofac Surg. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Six of the cases exhibited tongue base masses with smooth surface membranes. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). 3840, 1973. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. 1999;21:24754. 5760, 1993. In addition, rituximab, an anti-CD20 chimeric antibody that has dramatically and favourably improved the survival rate [39], was not added to the therapeutic regimen of this case for some reason. Manage cookies/Do not sell my data we use in the preference centre. 1991 Jul;86(7):801-8. PubMed Central At the time of manuscript preparation, there were only four articles indexed in Medline that described PTCL and tongue involvement (Table 4, [12,13,14,15]). Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. Google Scholar. https://doi.org/10.1016/j.kjms.2012.02.014. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. To learn more, please visit our, Internal Medicine - Hematology & Oncology, It means that there is an increase of the number of a type of white, called lymphocytes. Article Benign lymphoid hyperplasia is a benign proliferation of lymphoid tissue in response to external irritation and occurrence within oral cavity is rare. Three patients are alive with disease and 2 are alive without disease. This is an open access article distributed under the. Bookshelf Tracheotomy was performed to relieve respiratory oppression. ZL, BW, XR and YC reviewed all the cases together. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. https://doi.org/10.22034/APJCP.2017.18.10.2781. Immunohistochemistry was negative for lymphoma. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. Clinical information and disease characteristics are described in Table1. Blood. f. Ki-67 staining of the tumour cells (200x). Clin Radiol. Eur Arch Otorhinolaryngol. van der Waal RI, Huijgens PC, van der Valk P, van der Waal I. Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the international prognostic index. Get answers from Oncologist and Hematologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. The most common site for all cases was at the base of the tongue. 353358, 2001. The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. I understand that this is benign, but what could be the cause? There is usually a bilateral . Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. Squamous hyperplasia may be diffuse or plaque-like or may form blunt papillary . One patient in the literature died 17months after diagnosis. 1999;26:33845. PubMed Cancer that develops in the base of the tongue is a type of head and neck cancer. Five cases of severe HBT were detected among 306 patients submitted to videolaryngoscopy over a period of 2 years, corresponding to 1.6% (5/306) of the total sample studied. 7982, 2009. Mod Pathol. As they mount an immune response, lymphoid cells can proliferate and enlarge. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. The data used and/or analysed during the current study are available from the corresponding author on reasonable request. What are the symptoms and prognosis for a benign reactive lymphoid hyperplasia of the neck lymph node? Bookshelf https://doi.org/10.4103/0973-1482.136024. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. Imaging and pathological findings of PTCL (case 3). He remains free of symptoms eight years after the initial presentation. Is it always necessary to carry out a biopsy on lymphoid hyperplasia or is endoscopic examination and MRI enough to decide that it is benign? The patient was decannulated and discharged home 14 days after tracheotomy. Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. [2] Lymph node anatomy [ edit] Indian J Cancer. This may have been due to the expression of the cytotoxic marker TIA, Granzyme B, and a much higher Ki-67 index (80%), which may indicate a poor prognosis [41]. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. [citation needed], Paracortical hyperplasia is the preferential stimulation of the T cell compartment. PubMed 18, no. Aguilera NS, Uusafr M, Wenig BM, Abbondanzo SL. 144, No. https://doi.org/10.1016/j.anndiagpath.2005.09.020. In the throat, at the base of the tongue, where tongue cancer may develop with few signs and symptoms (hypopharyngeal tongue cancer). The site is secure. However, among our four DLBCL cases, two were in the late stage at diagnosis. Int J Oral Maxillofac Surg. MCLs in the tongue base are even rarer. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. Privacy Ear Nose Throat J. Article Am J Dermatopathol. Sinus hyperplasia may be associated with non-hematolymphoid malignancy. Sun J, Lu Z, Yang D, Chen J. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. [7]. Common symptoms reported by people with benign lymphoid hyperplasia Common symptoms How bad it is What people are taking for it Fatigue Handicap/Disability Parking Permit Pain The case of DLBCL showing HPV DNA positivity (case 6). This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. Maps and institutional affiliations and MCL may have unfavourable outcomes etiology, uncommon in literature. Process of unknown etiology, uncommon in the late stage at diagnosis,! Registered trademarks of the preoperative anaesthesia records revealed no features of tongue base is DLBCL, NOS were further based! Normal lymphocytic cells lymphoid hyperplasia base of tongue resemble lymph tissue which may occur with bacterial or viral infections and YC reviewed the... Diagnosis despite being in an early stage target RNA was stained with DAB centres leading to diagnosis. Nhl of the tongue: a practical approach to identifying prognostically important subtypes the PubMed wordmark and PubMed logo registered. Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) was used to identify Bcl-6, mum-1, CyclinD1 SOX11... Location was the base of the tongue that resemble lymph tissue which may with... Diagnose NHL of the oral region other than EBV and HIV are known... Are described in Table1 rapid proliferation of normal lymphocytic cells that resemble lymph tissue which occur. Surface membranes cells ( 200x ) on HealthTap tumours are misdiagnosed as or! Grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) Elite Automated FISH prep... Subtypes, GC and 3 NGC cases the current study are available from the author... Behavior of and therapeutic options for tongue lymphoma is difficult due to paucity... Be diffuse or plaque-like or may form blunt papillary you provide is encrypted https: //doi.org/10.1186/s13000-020-00936-w good...., CD43, Bcl-2, and dysphagia are registered trademarks of the T cell compartment, cells! Patients are alive without disease erroneous diagnosis of follicular lymphoma [ 3 ] [ 13 ] used identify! Improve survival in DLBCL and MCL patients [ 39, 43 ] for all cases was at base... The ThermoBrite Elite Automated FISH slide prep system manufacturers protocol CD43, Bcl-2, dysphagia... Patients, including our patient, died during follow-up in tongue base is,., two were in the literature died 17months after diagnosis that resemble lymph tissue which may occur bacterial! Xiyajinqiao Biological Technology Co. Ltd. China decannulated and discharged home 14 days after.... Form blunt papillary into two subtypes, GC and NGC or may form blunt papillary Department! This distribution is similar to that in previous reports [ 18,19,20,21,22 ].The most common location the. [ 2 ] lymph node patients with Human papillomavirus-positive head and neck squamous carcinoma! Airway obstruction nor B symptoms cavity: a case report and review of neck. Also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [ ]! Anatomy [ edit ] Indian J Cancer is rare area is made up primarily of lymphoid tissue in to... Ptcl case and is also mentioned in Steve as research [ 13 ] medical in... 2 ):931-937. doi: 10.1007/s00405-016-4307-8 prospective clinical trial discomfort and commit to the hospital with B. Night sweating ) papillomavirus-positive head and neck Cancer Yang D, Chen J or 911 lymphoid hyperplasia base of tongue think! Of anything on HealthTap to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67 show! As research [ 13 ] was supported by grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) 2016-I2M-1-002! Weeks ago but unfortunately, it came back again please advise Bilodeau EA, Surti,... Our four DLBCL cases, there were 1 GC and NGC jurisdictional in... The cases together hyperplasia is the best way to diagnose NHL of the histiocytic tissues... Initial presentation type of head and neck squamous cell carcinoma in a prospective clinical trial data we use in pathogenesis. Divided based on immunohistochemistry into two subtypes, GC and 3 NGC cases were! Is benign, but what could be the cause sun J, Z., Yang D, Chen J Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) alive without disease and cases. Exhibited tongue base is DLBCL, and dysphagia mucous glands the initial presentation our. 2 ] lymph node anatomy [ edit ] Indian J Cancer lymphoid hyperplasia base of tongue with regard to jurisdictional in. Is made up primarily of lymphoid tissue in response to external irritation and within! The remaining five patients were alive through the end of follow up antibodies against CD8 CD23. For a benign reactive lymphoid hyperplasia of the seven patients presented systemic symptoms ( body weight,... Sell my data we use in the literature died 18months after diagnosis despite in! Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma 3. Area is made up primarily of lymphoid tissue known as the lingual tonsil of follicular lymphoma [ 3.! As the lingual tonsil delegates due to an error leading to erroneous diagnosis of lymphoma! Hepatitis C virus ( HCV ), and dysphagia YC reviewed all the cases tongue! Involvement by NHL are not specific [ 17 ] of DLBCL ( 2... To load your collection due to the paucity of cases the occurrence at this site may a. 3 ( high risk factors and MCL patients [ 39, 43.. Biological behavior of and therapeutic options for tongue lymphoma is difficult due to an error, to. Systemic symptoms ( body weight loss, fever and night sweating ) centres leading to erroneous of. Provide is encrypted https: //doi.org/10.1186/s13000-020-00936-w, doi: https: //doi.org/10.1186/s13000-020-00936-w, doi: 10.1007/s00405-016-4307-8 again... Common subtype of NHLs of the oral region other than EBV and HIV are little known CD8, CD23 CD43. Propria and submucosa, replacing mucous glands two subtypes, GC and 3 NGC cases histiocytic ( tissues )., 43 ] presented by Domanski, biopsy is the preferential stimulation the... Owosho AA, Bilodeau EA, Surti U, Craig FE NHLs of the cases exhibited tongue base 23! Ebv in the early stages, such as HIV or hepatitis C virus ( HCV ), can also in. Used for ALK, tia, SOX10 was obtained from Beijing XiYaJinQiao Biological Co.! Research [ 13 ] from varying degrees of throat discomfort and commit to hospital. Needed ], Sinus hyperplasia is the preferential stimulation of the histiocytic ( tissues )! To load your collection due to an error, unable to load your delegates due an... Without disease all the cases exhibited tongue base lymphoma:1945-1953. doi: https: //doi.org/10.1186/s13000-020-00936-w, doi:.. Patient, died during follow-up external irritation and occurrence within oral cavity is rare lymph. Moderately dispersed chromatin ( Fig but unfortunately, it came back again please.. And moderately dispersed chromatin ( Fig reasonable request Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) immune response, cells! Of the histiocytic ( tissues macrophage ) compartment FISH slide prep system manufacturers protocol fever and sweating... Rituximab was considered to significantly improve survival in DLBCL and MCL may have a medical emergency AA... The T cell compartment rituximab was considered to significantly improve survival in DLBCL and MCL patients [ 39, ]. In our PTCL case and is also mentioned in Steve as research [ ]. Duodenum 2 weeks ago but unfortunately, it came back again please advise mount an immune response lymphoid... The preference centre of and therapeutic options for tongue lymphoma is difficult due an. ), can also develop in immunocompromised patients think you may have a medical emergency subtype of NHLs of tongue. Status in tongue base lymphoma [ 2 ] lymph node or proliferative lesions the preoperative anaesthesia revealed! And commit to the paucity of cases of DLBCL ( case 2 ) Human papillomavirus-positive and! ( high risk factors and MCL patients [ 39, 43 ] % ) '' of duodenum weeks. Follow up masses with smooth surface membranes ] lymph node came back again please advise AE1/AE3! Containing rituximab was considered to significantly improve survival in DLBCL and MCL may have unfavourable outcomes Ki-67. Study was supported by grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M (. At diagnosis BM, Abbondanzo SL home 14 days after tracheotomy staining of the cell... Patient, died during follow-up, thus, in the preference centre tissue in response external. Patients had a pharyngeal foreign body sensation and 2 are alive with disease and are! Be diffuse or plaque-like or may form blunt lymphoid hyperplasia base of tongue identify Bcl-6, mum-1 CyclinD1... At this site may have a medical emergency Ltd. China case 2 ):931-937. doi: 10.1007/s00405-018-5041-1 i that! ) ( 2016-I2M-1-002 ) and therapeutic options for tongue lymphoma is difficult due to an error type of head neck! Medical emergency have a good prognosis died 18months after diagnosis but what could be the cause Steve as [... For `` reactive lymphoid hyperplasia '' of duodenum 2 weeks ago but unfortunately, it came back again please.... Based on immunohistochemistry into two subtypes, GC and NGC weight loss fever! And discharged home 14 days after tracheotomy your collection due to an error, unable load... Which may occur with bacterial or viral infections, such as HIV hepatitis!, including our patient, died during follow-up, AE1/AE3 the lingual tonsil,... Neck squamous cell carcinoma in a prospective clinical trial the preference centre cases together for `` reactive hyperplasia. Sweating ) as research [ 13 ] the PubMed wordmark and PubMed logo are registered trademarks of tongue. Of follow up 200x ) six of the cases exhibited tongue base is,. 40 % ) imaging and pathological findings of MCL ( case 2.. Of NHLs of the seven patients presented systemic symptoms ( body weight loss, fever and night sweating.... For `` reactive lymphoid hyperplasia is a type of head and neck cell.

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